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标题: 转载：多中心临床试验的随机化方案及SAS程序 [打印本页]

作者: shiyiming 时间: 2010-11-8 09:33
标题: 转载：多中心临床试验的随机化方案及SAS程序
From crackman's blog on Baidu

<p><span> <font size="2" face="宋体">邹建东  熊宁宁  蒋萌  刘芳  卜擎燕  (南京中医药大学附属医院国家药品临床研究基地)</font></span></p>
<div> </div>
<div><font size="2" face="宋体">摘要  本文介绍一个多种疾病亚型、各中心分配例数不等的临床试验随机化方案的设计。设计规程包括随机化参数设定，随机化规定，SAS随机程序设计，由此产生随机数字，疾病亚型和试验中心随机编码、试验病例随机编码、处理组的随机编码及试验药物包装表。</font></div>
<div><font size="2" face="宋体">关键词  临床试验  随机化方案  SAS程序</font></div>
<div> </div>
<div><font size="2" face="宋体">     本文介绍一个典型案例的多中心临床试验随机化方案的设计，其设计规程包括随机化参数设定，随机化规定，SAS随机程序设计，由此产生随机数字，疾病亚型和试验中心随机编码、试验病例随机编码、处理组的随机编码及试验药物包装表等。</font></div>
<div><font size="2" face="宋体">一、多中心临床试验举例</font></div>
<div><font size="2" face="宋体">     某临床试验观察试验药物治疗截瘫的有效性，观察例数300例，其中完全性截瘫120例，不完全性截瘫180例，分试验组、对照组，安慰剂组，各处理组例数相等，有三家医院参加，各医院病例分配如下：医院甲：120例，其中完全性截瘫60例，不完全性截瘫60例；医院乙：90例，其中完全性截瘫30例，不完全性截瘫60例；医院丙：90例，其中完全性截瘫30例，不完全性截瘫60例。</font></div>
<div><font size="2" face="宋体">二、随机化参数设定</font></div>
<div><font size="2" face="宋体">种子数：以日期为种子数，20020520。</font></div>
<div><font size="2" face="宋体">总例数：300例。区组长度X区组数二总例数。区组长度：6，区组数：50。</font></div>
<div><font size="2" face="宋体">分层数：以参加临床试验的中心、疾病的亚型为分层因素。同时，确定各层分配的病例数。</font></div>
<div><font size="2" face="宋体">试验组数：分试验组、对照组、安慰剂组。</font></div>
<div><font size="2" face="宋体">分配比例：各处理组样本按1：1：1分配。</font></div>
<div><font size="2" face="宋体">三、随机化规定</font></div>
<div><font size="2" face="宋体">1．疾病亚型、试验中心编码随机化规定:</font><font size="2" face="宋体">疾病亚型按完全性截瘫、不完全性截瘫排序，各试验中心按甲、乙、丙排序，分别对应SAS随机程序产生的“疾病亚型试验中心随机数字”disease项下和center项下的随机数字，即得各中心的随机编码和疾病亚型的随机编码。</font></div>
<div><font size="2" face="宋体">2．试验病例分配随机化规定：试验病例分为三个处理组，SAS随机程序产生的“试验病例随机数字”rand项下1、2为A组，3、4为B组，5、6为C组。</font></div>
<div><font size="2" face="宋体">    “试验病例随机数字”符block和rand顺序纵向排列．以及本项规定．即得“试验病例随机编码表”。试验病例随机编码与试验药物随机编码相同。</font></div>
<div><font size="2" face="宋体">“试验病例随机编码表”按试验组别排序成为“试验用药包装表”。</font></div>
<div><font size="2" face="宋体">   3．处理组分配随机化规定：SAS随机程序产生的“处理组随机数字”group项下随机数字按顺序分别对应A、B、C组，按大小分别对应试验组，对照组和安慰剂组。</font></div>
<div><font size="2" face="宋体">四、SAS随机程序设计</font></div>
<div><font size="2" face="宋体">采用SAS 6．12统计软件包，设计随机化程序如下。</font></div>
<div><font size="2" face="宋体">  options ps：2000；</font></div>
<div><font size="2" face="宋体">proc plan seed：20020520；</font></div>
<div><font size="2" face="宋体">title ’疾病亚型试验中心随机数字’；</font></div>
<div><font size="2" face="宋体">factors disease= 2 center=3；</font></div>
<div><font size="2" face="宋体">proc plan seed=20020520；</font></div>
<div><font size="2" face="宋体">title’试验病例随机数字’；</font></div>
<div><font size="2" face="宋体">factors block=50 rand=6；</font></div>
<div><font size="2" face="宋体">output out = aaa；</font></div>
<div><font size="2" face="宋体">data bbb；</font></div>
<div><font size="2" face="宋体">set aaa；</font></div>
<div><font size="2" face="宋体">if rand<3 then group = ’A’；</font></div>
<div><font size="2" face="宋体">else if rand<5 then group = ’B’；</font></div>
<div><font size="2" face="宋体">else group = ’C’；</font></div>
<div><font size="2" face="宋体">D-number = -n-；</font></div>
<div><font size="2" face="宋体">proc print；</font></div>
<div><font size="2" face="宋体">title’试验病例随机编码表’；</font></div>
<div><font size="2" face="宋体">var block rand group D-number；</font></div>
<div><font size="2" face="宋体">proc sort out = ccc；by group；</font></div>
<div><font size="2" face="宋体">proc print data = ccc；</font></div>
<div><font size="2" face="宋体">title’试验用药包装表’；</font></div>
<div><font size="2" face="宋体">var block rand group D-number；</font></div>
<div><font size="2" face="宋体">proc plan seed = 20020520；</font></div>
<div><font size="2" face="宋体">title’处理组随机数字’；</font></div>
<div><font size="2" face="宋体">factors group = 3；</font></div>
<div><font size="2" face="宋体">run；</font></div>
<div><font size="2" face="宋体">五、随机化设计结果</font></div>
<div><font size="2" face="宋体"> 1．《疾病亚型、试验中心随机数字》SAS输出结果：</font></div>
<div align="center"><font size="2" face="宋体">中心编码分配随机数字     1</font></div>
<div align="center"><font size="2" face="宋体">The  PLAN  Procedure</font></div>
<p>
<table class="FCK__ShowTableBorders" border="0" cellspacing="0" cellpadding="0">
<tbody>
      <tr>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">Factor</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">Select</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">Levels</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">Order</font></div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">disease</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">Random</font></div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">center</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">3</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">3</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">Random</font></div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="142">
         <div align="center"> </div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">disease</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">- - center- -</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"> </div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="142">
         <div align="center"> </div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">2   3     1</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"> </div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="142">
         <div align="center"> </div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">1</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">2     1     3</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"> </div>
         </td>
      </tr>
</tbody>
</table>
</p>
<div><font size="2" face="宋体">2．《疾病亚型、试验中心随机编码及试验药物编码分配表》见表1。</font></div>
<div><font size="2" face="宋体">根据试验中心、疾病亚型随机编码和试验药物编码的序列，以及分配的病例数，编制本表。</font></div>
<div><font size="2" face="宋体">表：疾病亚型、试验中心随机编码及试验药物编码分配表</font></div>
<p>
<table border="1" cellspacing="0" cellpadding="0">
<tbody>
      <tr>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">疾病亚型</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">疾病亚型随机编码</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">实验中心（医院）</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">试验中心随机编码</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">药物编码</font></div>
         </td>
      </tr>
      <tr>
         <td rowspan="3" width="114">
         <div align="center"><font size="2" face="宋体">完全性瘫痪</font></div>
         </td>
         <td rowspan="3" width="114">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">甲医院</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">211~270</font></div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">乙医院</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">3</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">271~300</font></div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">丙医院</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">1</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">191~210</font></div>
         </td>
      </tr>
      <tr>
         <td rowspan="3" width="114">
         <div align="center"><font size="2" face="宋体">不完全性瘫痪</font></div>
         </td>
         <td rowspan="3" width="114">
         <div align="center"><font size="2" face="宋体">1</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">甲医院</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">061~120</font></div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">乙医院</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">1</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">001~060</font></div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">丙医院</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">3</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">121~180</font></div>
         </td>
      </tr>
</tbody>
</table>
</p>
<div><font size="2" face="宋体">注：①各中心按疾病亚型，分别保存试验药物。②各中心制定专人负责发放试验药物，根据合格受试者所属疾病亚型，按就诊先后顺序和试验药物编码从小到大顺序逐例发药。</font></div>
<div><font size="2" face="宋体">3．试验病例分配随机数字SAS输出结果</font></div>
<div align="center"><font size="2" face="宋体">试验病例分配随机数字  2</font></div>
<p>
<table class="FCK__ShowTableBorders" border="0" cellspacing="0" cellpadding="0">
<tbody>
      <tr>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">Factor</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">Select</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">Levels</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">Order</font></div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">block</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">50</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">50</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">Random</font></div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">rand</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">6</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">6</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">Random</font></div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="142">
         <div align="center"> </div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">block</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">----rand----</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"> </div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="142">
         <div align="center"> </div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">（区组</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">-随机数字--）</font></div>
         </td>
         <td valign="top" width="142">
         <div> </div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="142">
         <div align="center"> </div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">42</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">4  1  6  3  2  5</font></div>
         </td>
         <td valign="top" width="142">
         <div> </div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="142">
         <div align="center"> </div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">39</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">2  6  1  4  3  5</font></div>
         </td>
         <td valign="top" width="142">
         <div> </div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="142">
         <div align="center"> </div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">16</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">5  1  6  2  4  3</font></div>
         </td>
         <td valign="top" width="142">
         <div> </div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="142">
         <div align="center"> </div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">15</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">5  2  4  6  3  1</font></div>
         </td>
         <td valign="top" width="142">
         <div> </div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="142">
         <div> </div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">9</font></div>
         </td>
         <td valign="top" width="142">
         <div align="center"><font size="2" face="宋体">5  2  3  1  6  4</font></div>
         </td>
         <td valign="top" width="142">
         <div> </div>
         </td>
      </tr>
      <tr>
         <td valign="top" width="568" colspan="4">
         <div align="center"><font size="2" face="宋体">……</font></div>
         </td>
      </tr>
</tbody>
</table>
</p>
<div><font size="2" face="宋体">4．试验病例随机编码表（一级盲底）  按本文2.2“试验病例分配随机化规定”，SAS输出结果：</font></div>
<div align="center"><font size="2" face="宋体">试验病例随机编码表（一级盲底）3</font></div>
<div align="center">
<table class="FCK__ShowTableBorders" border="0" cellspacing="0" cellpadding="0">
<tbody>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">Obs</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">block</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">rand</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">group</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">D-number</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">(顺序号</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">区组</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">随机数字</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">实验组别</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">药物编码</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">1</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">42</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">4</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">B</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">1</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">42</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">1</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">A</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">3</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">42</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">6</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">C</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">3</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">4</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">42</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">3</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">B</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">4</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">5</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">42</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">A</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">5</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">6</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">42</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">5</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">C</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">6</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"> </div>
         </td>
         <td width="114">
         <div align="center"> </div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">……</font></div>
         </td>
         <td width="114">
         <div align="center"> </div>
         </td>
         <td width="114">
         <div align="center"> </div>
         </td>
      </tr>
</tbody>
</table>
</div>
<div><font size="2" face="宋体">5．《处理组分配随机数字（二级盲底）》SAS输出结果：</font></div>
<div align="center"><font size="2" face="宋体">处理组分配随机数字（二级盲底）4</font></div>
<div align="center"><font size="2" face="宋体">The  PLAN  Procedure</font></div>
<p>
<table class="FCK__ShowTableBorders" border="0" cellspacing="0" cellpadding="0">
<tbody>
      <tr>
         <td width="142">
         <div align="center"><font size="2" face="宋体">Factor0</font></div>
         </td>
         <td width="142">
         <div align="center"><font size="2" face="宋体">Select</font></div>
         </td>
         <td width="142">
         <div align="center"><font size="2" face="宋体">Levels</font></div>
         </td>
         <td width="142">
         <div align="center"><font size="2" face="宋体">Order</font></div>
         </td>
      </tr>
      <tr>
         <td width="142">
         <div align="center"><font size="2" face="宋体">group</font></div>
         </td>
         <td width="142">
         <div align="center"><font size="2" face="宋体">3</font></div>
         </td>
         <td width="142">
         <div align="center"><font size="2" face="宋体">3</font></div>
         </td>
         <td width="142">
         <div align="center"><font size="2" face="宋体">Random</font></div>
         </td>
      </tr>
      <tr>
         <td width="142">
         <div align="center"> </div>
         </td>
         <td width="142">
         <div align="center"><font size="2" face="宋体">- group-</font></div>
         </td>
         <td width="142">
         <div align="center"> </div>
         </td>
         <td width="142">
         <div align="center"> </div>
         </td>
      </tr>
      <tr>
         <td width="142">
         <div align="center"> </div>
         </td>
         <td width="142">
         <div align="center"><font size="2" face="宋体">3  1  2</font></div>
         </td>
         <td width="142">
         <div align="center"> </div>
         </td>
         <td width="142">
         <div align="center"> </div>
         </td>
      </tr>
</tbody>
</table>
</p>
<div> </div>
<div><font size="2" face="宋体">按本文“处理组分配随机化规定”，A组为实验组，B组为安慰剂组，C组为对照组。</font></div>
<div><font size="2" face="宋体">6．试验药物包装表  按《试验病例随机编码表》的组别排序成为《试验药物包装表》，SAS输出结果：</font></div>
<div align="center"><font size="2" face="宋体">试验药物包装表5</font></div>
<div align="center">
<table class="FCK__ShowTableBorders" border="0" cellspacing="0" cellpadding="0">
<tbody>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">Obs</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">block</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">rand</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">group</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">D-number</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">(顺序号</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">区组</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">随机数字</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">实验组别</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">药物编码</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">1</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">42</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">1</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">A</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">42</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">A</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">5</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">3</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">39</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">A</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">7</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">4</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">39</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">1</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">A</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">9</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">5</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">16</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">1</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">A</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">14</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">6</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">16</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">A</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">16</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">7</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">15</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">A</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">20</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">8</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">15</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">1</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">A</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">24</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">9</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">9</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">2</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">A</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">26</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"><font size="2" face="宋体">10</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">9</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">1</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"><font size="2" face="宋体">A</font></div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">28</font></div>
         </td>
      </tr>
      <tr>
         <td width="114">
         <div align="center"> </div>
         </td>
         <td width="114">
         <div align="center"> </div>
         </td>
         <td width="114">
         <div align="center"><font size="2" face="宋体">……</font></div>
         </td>
         <td valign="top" width="114">
         <div align="center"> </div>
         </td>
         <td width="114">
         <div align="center"> </div>
         </td>
      </tr>
</tbody>
</table>
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